What are Adrenal Symptoms?

There are many symptoms associated with the adrenal gland which are related to the over-production or under-production of the adrenal hormones. Over-production of adrenal hormones is usually due to an abnormal growth of one of the adrenal glands and the symptoms that appear are due to which hormone is being made in excess. Most commonly these symptoms come from a benign adrenal gland tumor and thus a simple mini-adrenal scope operation can cure the symptoms by removal of the adrenal tumor. This website discusses adrenal tumors and adrenal surgery in great detail. Dr Carling is the world's most experienced adrenal surgeon.

When you have an adrenal tumor, you can have numerous symptoms. Since many doctors are inexperienced (even smart ones) and only see a handful during their career, they don’t have a significant experience with these tumors. Thus, it is very important for patients to know about the symptoms of adrenal tumor disease. A great doctor will always perform a very careful history and physical examination to identify signs and symptoms of adrenal tumor disease.

High Blood Pressure Symptoms. One of the hallmarks of adrenal tumors is high blood pressure, also known as hypertension. Tumors that overproduce catecholamines called pheochromocytoma, as well as aldosterone producing tumors, also known as aldosteronoma (Conn tumor) and cortisol producing tumors (causing Cushing syndrome) can all cause high blood pressure.


Symptoms of Excess Aldosterone Secretion: Conn's Syndrome

If the adrenal tumor is overproducing aldosterone then you have a disease called primary hyperaldosteronism, also called Conn's Syndrome (Conn's tumor) after Dr Conn who first described this disease. The signs and symptoms associated with Conn's Syndrome (hyper-aldosteronism) includes low potassium in the blood which can cause you to have go urinating at night, with frequent urination as well as muscle cramps and heart palpitations (feeling your heart racing). High blood pressue is also associated with excess production of aldosterone (Conn's Syndrome). If you ever have high blood pressure and low potassium you should definitely be investigated to make sure you don’t have an aldosterone producing adrenocortical tumor. We have an entire section of this website dedicated to the diagnosis and treatment of hyper-aldosteronism (Conn's Syndrome).

Most patients with primary hyperaldosteronism (aldosteronoma; Conn tumor) have high blood pressure. If you have high blood pressure especially if you’re relatively young and have no other risk factors such as diabetes or a family history, you need to make sure you don’t have an adrenal tumor over producing aldosterone. It is important to know that almost 50% of all patients with primary hyperaldosteronism (aldosteronoma; Conn tumor) are asymptomatic. They don’t have any significant symptoms. They may feel normal, maybe the only sign is high blood pressure. However, if they don’t have their adrenal tumor removed the patients are at a tenfold increased risk of heart arrhythmias, stroke and heart attacks.

How Common is Conn's Syndrome and Hyperaldosteronism? Conns' Syndrome and the adrenal tumor that causes it are much more common than you would think--with many people not diagnosed. It is estimated that almost 10% of all patients who have elevated blood pressure (hypertension) have underlying primary hyperaldosteronism as the cause and thus all doctors should be on the lookout for it. It is very important to identify these individuals since a simple operation (adrenalectomy) can dramatically reduce the risk of dying prematurely from heart disease and stroke.


Symptoms of Cortisol Excess: Cushing's Syndrome.

If the adrenal tumor is overproducing cortisol, you will develop symptoms of Cushing’s syndrome. The symptoms of Cushing’s syndrome include weight gain and central body obesity, that is you store fat especially around your abdomen. Your face might develop more round features and you develop fat deposits above your collar bones and on your back (called buffalo hump). Patients may develop problems with easy bruising, with thin skin and poor wound healing.

Other symptoms of excess cortisol production from the adrenal gland include stretch marks on the skin that tend to be purple (often on the abdomen) and muscle weakness in your extremities (arms and legs). It can also affect how you feel and how your brain works. Excess cortisol can also cause depression and anxiety symptoms. It can cause hirsutism in many women (facial hair formation in women) Many patients with Cushing’s syndrome have high blood pressure (hypertension), weak bones, osteopenia and osteoporosis. The blood sugar may be increased, and patients can even develop diabetes. Also, many patients have low potassium and high white count cells.

Do all patients with excess cortisol production have symptoms? Actually they do not. Many patients that have adrenal tumors that overproduce cortisol may be asymptomatic (have no symptoms). That means they may not have any obvious symptoms. These patients were often referred to as having subclinical Cushing’s syndrome. (The terms subclinical means that there is a hormone disturbance but it has yet to be overt and easily diagnosed just clinically; i.e. by a history and physical exam performed by a doctor). However, an astute doctor can often identify that many patients have slight to obvious underlying obesity, hypertension, hypoglycemia, pre-diabetes or frank diabetes mellitus. Often this is referred to as metabolic syndrome.

It is very important to identify patients with overproduction of cortisol (whether overt or subclinical Cushing’s syndrome) since a simple operation (adrenalectomy) can dramatically improve the patient’s quality of life, cure hyperglycemia (pre-diabetes), hypertension and prevent the risk of dying prematurely from heart disease and stroke.


Symptoms of Excess Adrenal Medulla Hormone Production: The Pheochromocytoma

A pheochromocytoma it a tumor growing from the inner part of the adrenal gland (the medulla) and they over produce fight or flight hormones (catecholamines; also called epinephrine, metanephrine, adrenaline, noradrenaline and dopamine). Thus the symptoms of a pheochromocytoma are the symptoms of panic and anxiety.

Pheochromocytoma is a tumor that overproduce catecholamines. These hormones are also called epinephrine, metanephrine, adrenaline, noradrenaline and dopamine. These are hormones that are involved in our fight or flight mechanism. If you ever remember getting scared you can probably remember that your heart started racing and beating very hard and maybe you developed some flushing or you got very pale (pallor) and started sweating. This is the function of the fight or flight hormones of the adrenal gland. These hormones are produced in the medulla (core; inner layer) of the adrenal gland.

Symptoms of pheochromocytoma often come and go. Many patients with pheochromocytoma have very variable symptoms. They can have spells that are extremely variable with differing symptoms each time, but the symptoms typically include heart palpitations, pallor, flushing, tremors, headaches, and sweating. In other words, the patients "freak out" and have a feeling of impending doom and anxiety. They get sweaty, their heart races and they have anxiety.

The symptoms may be completely spontaneous but sometimes precipitated by change in the posture, anxiety, certain medications or maneuvers that increase the intra-abdominal pressure (for instance going to the bathroom). The physical signs when you examine patients with pheochromocytoma may include hypertension, which may occur just occasionally (paroxysmal) or sustained, as well orthostatic hypotension (meaning when you lay down the blood pressure goes down). Patients may develop tremors, pallor or in extreme case cases even retinopathy, fevers, cardiogeneic (heart) shock and failure. We have an entire section of this website dedicated to the diagnosis and treatment of pheochromocytomas.

Symptoms of Adrenal Cancer

Adrenocortical cancer (ACC) can cause many various symptoms. Common symptoms are due to a "mass effect" which simply means the tumor is growing big so it is pushing on surrounding structures and organs in the abdomen. This can manifest itself as flank, or abdominal pain or an increase of girth (a growing waiste line). Fluctuations in weight can also be seen, both weight loss and weight gain.

About half of all adrenocortical cancers over produce cortisol. Thus, patients can develop signs and symptoms of Cushing’s syndrome (See symptoms of Cushing’s syndrome).

Adrenocortical cancer can also overproduce sex steroid hormones (androgens and estrogens). In women, increased androgen can lead to hirsituism (development or increase of facial hair), acne, absence or changes in the menstrual cycle and increased libido (sex drive). In men, increased estrogen can cause gynecomastia (enlarged breast that are often tender), and problems with libido (sex drive), and erectile dysfunction.

If you have an adrenal tumor and overproduction of sex steroid hormones, this almost always occurs in the setting of a cancerous tumor, so that is very important to know. Aldosterone producing adrenocortical cancer, although rare can lead to signs and symptoms of primary hyperaldosteronism. (See symptoms of primary hyperaldosteronism). Patients with adrenocortical cancer can also be completely asymptomatic (30 to 50 %) but also have hypertension, osteoporosis, diabetes, and low potassium. We have an entire section on the diagnosis and treatment of adrenal cancer.